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Published TCIMAIL newest issue No.197
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RET Kinase Inhibitor: RPI 1
RPI 1 (1) is a cell permeable ret/ptc1 kinase inhibitor and selectively inhibits the anchorage-independent growth of NIH3T3 transformants expressing the ret/ptc1 gene (NIH3T3ptc1 cells) (IC50 = 0.97 μM).1) By the tyrosine kinase assay using epidermal growth factor receptor as a target, it has been demonstrated that the inhibitory manner is ATP-competitive. 1 also inhibits hepatocyte growth factor-induced Met tyrosine phosphorylation (Tyr1234/Tyr1235) dose-dependently.2)
ret/ptc kinase: Rearranged in transformation/papillary thyroid carcinomas kinase
MET: mesenchymal–epithelial transition factorThis product is for research purpose only.
ret/ptc kinase: Rearranged in transformation/papillary thyroid carcinomas kinase
MET: mesenchymal–epithelial transition factor
References
- 1)Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative
- 2)Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1
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