Published TCIMAIL newest issue No.197
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Tyrosine Kinase Inhibitor: Tyrphostin AG1478
No.173(April 2017)
Tyrphostin AG1478 (1) is an inhibitor of protein tyrosine kinase and is highly selective for epidermal growth factor receptor (EGFR).1) 1 can inhibit EGFR with IC50 of 3 nM, while the IC50s for other kinases are higher as shown in the Table.1) It was reported that the combination of 1 with cytostatic drugs, Cisplatin or Paclitaxel, induces a synergistic effect of growth inhibition of endometrial cancer cells.2)
References
- 1)Tyrosine kinase inhibition: An approach to drug development
- 2)Synergistic anti-neoplastic effect of AG1478 in combination with cisplatin or paclitaxel on human endometrial and ovarian cancer cells
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