Published TCIMAIL newest issue No.197
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Tyrosine Kinase Iinhibitor: Biochanin A
No.172(January 2017)
Biochanin A (1) is an estrogenic substance and is isolated from various plants.1,2) 1 inhibits tyrosine protein kinase.3)
Through much research, data supporting activation of PPARα and PPARγ by 1 have been reported.4) 1 also induces adipogenesis in 3T3-L1 cells.5) In adipose-derived stem cells (ADSCs), 1 inhibits the adipogenic differentiation and promotes the osteogenic differentiation.6)
PPAR: peroxisome proliferator-activated receptor
References
- 1)A review of the effects of plant estrogenic substances on animal reproduction
- 2)Biochanin A and formononetin content in red clover varieties at several maturity stages
- 3)Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones
- 4)Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
- 5)Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in vitro
- 6)Biochanin A promotes osteogenic but inhibits adipogenic differentiation: Evidence with primary adipose-derived stem cells
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