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Published TCIMAIL newest issue No.197
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DRB: A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
No.164(January 2015)
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB, 1) is a selective inhibitor of transcription elongation by RNA polymerase II, further inhibiting mRNA synthesis in eukaryotic cells.1) The inhibition can trigger p53-dependent apotosis of tumor cells.2) DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat)3).
References
- 1)Selective inhibitation of transcription elongation
- 2)Inhibition of RNA polymerase II as a trigger for the p53 response
- 3)Inhabitation of HIV transcription
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