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Published TCIMAIL newest issue No.197
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A Bioactive Polyphenol in Hops and Beer
Hops (Humulus lupulus) includes not only bitter and aroma components but also some polyphenols. Xanthohumol, a kind of polyphenol, has a structure of prenylchalcone and shows various bioactivities.1,2) For example, the activities have been reported as an antiproliferative activity of cancer,3) a chemopreventive activity,4) a bone resorption inhibition activity,5) an antioxidative activity,6) a diacylglycerol acyltransferase (DGAT, an enzyme related to lipogenesis) inhibition activity7) and so on.
References
- 1)Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
- 2)Pharmacognostic and pharmacological profile of Humulus lupulus L.
- 3)Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines
- 4)Cancer chemopreventive activity of xanthohumol, a natural product derived from hop
- 5)Bone resorption inhibitors from hop extract
- 6)Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro
- 7)Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus
