Guanidinylation [Synthetic Reagents]

　The guanidine structure is a basic skeleton of bioactive substances. For instance, saxitoxin and tetrodotoxin derived from puffer toxin, and batzelladine A as an HIV inhibitor in sea sponge are known as compounds bearing a guanidino group. Also pharmaceutical compounds like antimalarial and antimicrobial agents often have guanidine structure. Guanidinylation reagents are used for the synthesis of guanidine derivertives in the drug discovery field.¹⁾