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Published TCIMAIL newest issue No.197
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Cyclitol
No.166(July 2015)
D-Pinitol (1) is one of cyclitols occurring in various plants, Leguminosae (Fabaceae), Pinaceae etc.1) 1 suppresses increasing blood-sugar levels in normal and diabetes-induced mice2) and the mechanism of action of 1 does not augment the effect of insulin but might involve an interaction with part of a cellular signaling pathway that links insulin with glucose transport.3)
On the other hand, It was reported that, in polycystic ovary syndrome, D-chiro-Inositol, de-methyl-moiety of 1, reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities of syndrome X.4)
In addition, it was reported that 1 is accumulated in plant and functions as an osmolyte under the salt stress condition including water deficit.5,6)
This product is for research purpose only.
References
- 1)A review on insulinomimetic pinitol from plants
- 2)Pinitol – a new anti-diabetic compound from the leaves of Bougainvillea spectabilis
- 3)Insulin-like effect of pinitol
- 4)Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome
- M. J. Iuorno, D. J. Jakubowicz, J.-P. Baillargeon, P. Dillon, R. D. Gunn, G. Allan, J. E. Nestler, Endocr. Pract. 2002, 8, 417.
- 5)Salt stress perception and plant growth regulators in the halophyte Mesembryanthemum crystallium
- 6)Pinitol accumulation in mature leaves of white clover in response to a water deficit
Related Compounds
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