Maintenance Notice (5:15 AM - 4:55 PM May 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Merci de sélectionner la quantité
Odorless Reagent for the Introduction of S-tert-Butyl Group
2-(tert-Butyl)isothiouronium Bromide (1) is an odorless solid utilized as a reagent to introduce the tert-butylthio group. For instance, introduction of the tert-butylthio group proceeds by treating 1 with arylhlides in high yields in the presence of palladium catalyst.1) In addition, the tert-butyl group can be removed by treating with Brønsted acid or Lewis acid and a thioketal like 2 is afforded in the presence of acetone. On the other hand, by adding a catalytic amount of base, 1 can introduce the tert-butylthio group to ethyl bromoacetate.2)
Related Products
- B6315
- 2-(tert-Butyl)isothiouronium Bromide
- T2184
- Tris(dibenzylideneacetone)dipalladium(0) (= Pd2(dba)3)
- T0519
- Triphenylphosphine (= PPh3)
- P1008
- Potassium tert-Butoxide (= KOtBu)
- T1663
- Scandium(III) Triflate (= Sc(OTf)3)
- S0547
- Sodium Ethoxide (= EtONa)
References
- 1) Improved, Odorless Access to Benzo[1,2-d;4,5-d']-bis[1,3]dithioles and Tert-butyl Arylsulfides via C-S Cross Coupling
- 2) Decomposition of S-alkylisothiouronium salts under anhydrous conditions - application to a facile preparation of nonsymmetrical dialkyl sulfides
