Maintenance Notice (4:30 AM - 11:00 AM December 21, 2024): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Merci de sélectionner la quantité
CAS RN: 67-03-8 | Numéro de produit: T0181
Thiamine Hydrochloride
×
![]()
×
Pureté: >98.0%(T)(HPLC)
Synonymes
- Aneurine Hydrochloride
- Thiamine Chloride Hydrochloride
- Vitamin B1 Hydrochloride
Documents de produit:
| Taille | Prix unitaire | Belgique | Japon * | Quantité |
|---|---|---|---|---|
| 25G |
€23.00
|
7 | ≥100 |
|
| 100G |
€64.00
|
2 | 33 |
|
| 500G |
€209.00
|
1 | 9 |
|
*Le délai de livraison pour des produits disponibles en stock en Belgique est 1 à 2 jours
*Le délai de livraison pour des produits disponibles en stock en Japon est 1 à 2 semaines (sauf des produits réglementés et des envois avec de la glace carbonique)
Informations supplémentaires sur le produit:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Numéro de produit | T0181 |
| Pureté / Méthode d'analyse | >98.0%(T)(HPLC) |
| Formule moléculaire / poids moléculaire | C__1__2H__1__7ClN__4OS·HCl = 337.26 |
| Etat physique (20 ° C) | Solid |
| Condition de stockage | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Stocker sous gaz inerte | Store under inert gas |
| Condition à éviter | Light Sensitive,Hygroscopic |
| CAS RN | 67-03-8 |
| CAS RN connexes | 129659-07-0 |
| Numéro de registre de Reaxys | 3851771 |
| Identifiant de la substance PubChem | 87576174 |
| Indice Merck (14) | 9295 |
| Numéro MDL | MFCD00012780 |
Spécifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Solubility in Water | almost transparency |
| Water | max. 5.0 % |
Propriétés
SGH
Lois connexes:
| Numéros CE | 200-641-8 |
| RTECS # | XI7350000 |
Informations de transport:
| N ° SH (import / export) (TCI-E) | 2936220000 |
Application
Thiamine (Vitamin B1): One of Essential B Vitamins with Many Important Functions in All Tissues
Thiamine, also known as vitamin B1, is one of essential B vitamins that has many important functions in all tissues.1-3) Two types of water soluble thiamine salts, thiamine hydrochloride [T0181] and thiamine nitrate [T0182], are commonly used to products.4) Thiamine pyrophosphate (diphosphate) chloride [T0183] is the biologically active form of thiamine. In addition, thiamine hydrochloride is also used as an efficient catalyst for chemical reactions.7,8) For your reference, [A2633] is a key synthetic intermediate of thiamin. (The product is for research purpose only.)
References
- 1) Thiamin biosynthesis in prokaryotes (a review)
- 2) Molecular mechanisms of thiamine utilization (a review)
- 3) The structural and biochemical foundations of thiamin biosynthesis (a review)
- 4) Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution
- 5) Analytical profile of thiamin hydrochloride (a review of the preparation, physical properties, metabolism, methods of determination, etc., of thiamin)
- 6) Determination of thiamine by high-performance liquid chromatography
- 7) Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols
- 8) Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium
Application
Synthesis of Formamide Derivatives Catalyzed by Vitamin B1 Hydrochloride
N-Formination of aniline using VB1 as a catalyst:
A mixture of aniline (5 mmol), formic acid (1 mL), and VB1 (0.1 mmol, 2 mol%) is heated at 80 °C under stirring for 10 minutes. After completion of the reaction as indicated by TLC, 20 mL of EtOAc is added and washed with 5% HCl aq., 5% Na2CO3 aq., and brine. Then, the organic layer is dried over MgSO4 and concentrated to afford N-formylaniline in 96% yield without further purification.
A mixture of aniline (5 mmol), formic acid (1 mL), and VB1 (0.1 mmol, 2 mol%) is heated at 80 °C under stirring for 10 minutes. After completion of the reaction as indicated by TLC, 20 mL of EtOAc is added and washed with 5% HCl aq., 5% Na2CO3 aq., and brine. Then, the organic layer is dried over MgSO4 and concentrated to afford N-formylaniline in 96% yield without further purification.
References
- A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst
Application
Thiamine Catalyzed Benzoin Condensation: Synthesis of Fluorobenzoins
Typical procedure : Synthesis of 4,4’-Difluorobenzoin
1,2-Bis(4-fluorophenyl)-2-hydroxyethanone is synthesized by condensation of 4-fluorobenzaldehyde (5.0 g, 40 mmol) in the presence of thiamine hydrochloride (0.67 g, 2.0 mmol) and sodium hydroxide (0.20 g, 5.0 mmol) in ethanol. The reaction is carried out at 50°C for 48 h and then the mixture is cooling on ice. A formed crude product is filtered and washed with ice cold 75% ethanol. The material is recrystallized from ethanol to give white crystals in 75% yield.
1,2-Bis(4-fluorophenyl)-2-hydroxyethanone is synthesized by condensation of 4-fluorobenzaldehyde (5.0 g, 40 mmol) in the presence of thiamine hydrochloride (0.67 g, 2.0 mmol) and sodium hydroxide (0.20 g, 5.0 mmol) in ethanol. The reaction is carried out at 50°C for 48 h and then the mixture is cooling on ice. A formed crude product is filtered and washed with ice cold 75% ethanol. The material is recrystallized from ethanol to give white crystals in 75% yield.
References
PubMed Litterature
Articles / Brochures
TCIMail
[Product Highlights] Synthesis of Formamide Derivatives Catalyzed by Vitamin B1 HydrochlorideDocuments de produit (Note : Pour certains produits, les tableaux analytiques ne sont pas disponibles.)
Fiche de sécurité (FDS)
S'il vous plaît sélectionnez la langue.
La FDS demandée n'est pas disponible.
Nous contacter pour plus d'informations.
Spécifications
CoA et autres Certificats
Veuillez remplir le numéro de lot
Le numéro de lot saisi est incorrect. Veuillez saisir uniquement 4-5 caractères alphanumériques avant le trait d'union.
Exemple de CoA
Il s'agit d'un échantillon CoA qui peut ne pas représenter un lot récemment fabriqué du produit.
Un échantillon CoA pour ce produit n'est pas disponible pour le moment.
Graphiques analytiques
Veuillez remplir le numéro de lot
Le numéro de lot saisi est incorrect. Veuillez saisir uniquement 4-5 caractères alphanumériques avant le trait d'union.
Le tableau analytique demandé n'est pas disponible. Nous sommes désolés pour ce désagrément.