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CAS RN: 133745-75-2 | Numéro de produit: F0335
N-Fluorobenzenesulfonimide [Fluorinating Reagent]
![Thumbnail of N-Fluorobenzenesulfonimide [Fluorinating Reagent]](/medias/F0335.jpg?context=bWFzdGVyfHJvb3R8MTQwODh8aW1hZ2UvanBlZ3xhR1EzTDJneU1DODRPVE0xTVRRMU56azVOekV3TDBZd016TTFMbXB3Wnd8YjJiMjcwMDMzNzU3YTA0ZWZmYWQxZTRkZGU1NzE3MDY2N2FlMzhlNmU0YWM2OTg1NjAxM2FiZmY3OTUzMDlmNg "N-Fluorobenzenesulfonimide [Fluorinating Reagent]")
![Chemical Structure of N-Fluorobenzenesulfonimide [Fluorinating Reagent]](/medias/F0335.jpg?context=bWFzdGVyfHJvb3R8NDYzMDV8aW1hZ2UvanBlZ3xhREZrTDJnMFlTODRPVEl4TmpnNU16VTRNelkyTDBZd016TTFMbXB3Wnd8NDJkMWVkY2MxYjM2N2FjOWNlNDk2ZjkxOWJhNjljYWEwNmQzMzY5ZTBhYWFlMDYyOGMxM2M5NmIzNjA3MmVhOQ "N-Fluorobenzenesulfonimide [Fluorinating Reagent]")
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![N-Fluorobenzenesulfonimide [Fluorinating Reagent]](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "N-Fluorobenzenesulfonimide [Fluorinating Reagent]")
Pureté: >98.0%(T)(HPLC)
Synonymes
- N-Fluorobis(phenylsulfonyl)amine
- NFSI
- NFBS
Documents de produit:
| Taille | Prix unitaire | Belgique | Japon * | Quantité |
Informations d'expédition
|
|---|---|---|---|---|---|
| 5G |
€38.00
|
2 | ≥100 |
|
|
| 25G |
€147.00
|
2 | ≥60 |
|
*Stock disponible en Belgique : Expédition le jour même
*Stock disponible au Japon : Veuillez consulter la simulation d'expédition pour une estimation des délais d'expédition (hors articles réglementés et expédition avec Carboglace)
| Numéro de produit | F0335 |
Pureté / Méthode d'analyse 
|
>98.0%(T)(HPLC) |
| Formule moléculaire / poids moléculaire | C__1__2H__1__0FNO__4S__2 = 315.33 |
| Etat physique (20 ° C) | Solid |
| Condition de stockage
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 133745-75-2 |
| Numéro de registre de Reaxys | 5348902 |
| Identifiant de la substance PubChem | 87570107 |
| SDBS | 19601 |
| Numéro MDL | MFCD00144885 |
Spécifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Iodometric Titration) | min. 98.0 % |
| Melting point | 115.0 to 119.0 °C |
Propriétés
| Point de fusion | 115 °C |
SGH
| Pictogramme |
|
| Mot de signal | Attention |
| Mentions de danger | H315 : Provoque une irritation cutanée. H319 : Provoque une sévère irritation des yeux. H341 : Susceptible d'induire des anomalies génétiques. |
| Conseils de prudence | P501 : Éliminer le contenu/récipient dans une installation d'élimination des déchets agréée. P201 : Se procurer les instructions spéciales avant utilisation. P264 : Se laver la peau soigneusement après manipulation. P280 : Porter des gants de protection/ des vêtements de protection/ un équipment de protection des yeux/ du visage/ auditive. P308 + P313 : EN CAS d'exposition prouvée ou suspectée: consulter un médecin. P337 + P313 : Si l'irritation oculaire persiste: consulter un médecin. |
Lois connexes:
Informations de transport:
| N ° SH (import / export) (TCI-E) | 2935909099 |
Application
TCI Practical Example: One-Pot Palladium-Catalyzed Fluorosulfonylation of an Aryl Bromide Using DABSO and NFSI
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Used Chemicals
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Procedure
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To a solution of 4-bromobiphenyl (1.17 g, 5.00 mmol), DABSO (721 mg, 3.00 mmol), and PdCl2(Amphos)2 (177 mg, 0.25 mmol) in anhydrous isopropyl alcohol (20 mL) was added triethylamine (2.1 mL, 15 mmol) at room temperature and the mixture was stirred at 75 °C for 23 hours. The suspension was cooled at room temperature and NFSI (2.36 g, 7.5 mmol) was added and the reaction mixture stirred for 3 hours until completion. The solvent was removed under reduced pressure. The residue was diluted with ethyl acetate (20 mL) and filtrated through celite pad. The filtrate was washed with saturated aqueous Na2S2O3 solution (20 mL) and brine (20 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by medium pressure preparative chromatography (ethyl acetate:hexane = 2:98 - 5:95 on silica gel) to give compound 1 as a white solid (928 mg, 79%).
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:9, Rf = 0.57) and UPLC-MS.
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Analytical Data
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Compound 1
1H NMR (400 MHz, CDCl3); δ 8.12–8.04 (m, 2H), 7.86–7.80 (m, 2H), 7.67–7.58 (m, 2H), 7.44-7.55 (m, 3H).
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Lead Reference
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- One-pot palladium-catalyzed synthesis of sulfonyl fluorides from aryl bromides
Application
An Enantioselective Fluorination of α-Branched Aldehydes Using Newly Developed Chiral Amine Catalyst
Typical Procedure (synthesis of 2-fluoro alcohol; Ar=Ph, R1=CH3):
To a solution of the chiral amine catalyst [E1267] (20 mg, 0.026 mmol, 10 mol%) in toluene (0.54 mL) is added 3,5-dinitrobenzoic acid (5.5 mg, 0.026 mmol, 10 mol%), 2-phenylpropionaldehyde (52 mg, 0.39 mmol, 1.5 eq.), and N-fluorobenzenesulfonimide (NFSI) (0.26 mmol, 82 mg, 1 eq.) at 0 °C. The reaction mixture is stirred at 0 °C for 48 h, then poured into CH3OH/CH2Cl2 (1:4, 1.3 mL) at 0 °C. To this solution, NaBH4 (1.6 mmol, 6 eq.) is added, and the mixture is stirred at room temperature for 1 h. The reaction is quenched with saturated aq.NH4Cl, and the mixture is extracted with Et2O. The organic layer is dried over Na2SO4, and concentrated. The residue is purified by silica gel chromatography (eluent: hexane/ethyl acetate = 3/1) to give (S)-2-fluoro-2-phenylpropan-1-ol (34.5 mg, 86% yield based on NFSI, 95% ee) as a white solid.
To a solution of the chiral amine catalyst [E1267] (20 mg, 0.026 mmol, 10 mol%) in toluene (0.54 mL) is added 3,5-dinitrobenzoic acid (5.5 mg, 0.026 mmol, 10 mol%), 2-phenylpropionaldehyde (52 mg, 0.39 mmol, 1.5 eq.), and N-fluorobenzenesulfonimide (NFSI) (0.26 mmol, 82 mg, 1 eq.) at 0 °C. The reaction mixture is stirred at 0 °C for 48 h, then poured into CH3OH/CH2Cl2 (1:4, 1.3 mL) at 0 °C. To this solution, NaBH4 (1.6 mmol, 6 eq.) is added, and the mixture is stirred at room temperature for 1 h. The reaction is quenched with saturated aq.NH4Cl, and the mixture is extracted with Et2O. The organic layer is dried over Na2SO4, and concentrated. The residue is purified by silica gel chromatography (eluent: hexane/ethyl acetate = 3/1) to give (S)-2-fluoro-2-phenylpropan-1-ol (34.5 mg, 86% yield based on NFSI, 95% ee) as a white solid.
References
Application
Copper-catalyzed Direct Amidation of Heterocycles with N-Fluorobenzenesulfonimide
Typical Procedure:
In a dry 25 mL round-bottom flask, thiophene (0.5 mmol, 1 eq.), NFSI (0.6 mmol, 1.2 eq.) and CuI (5 mol%) are dissolved in DCE (3 mL), the resulting mixture is put into a preheated oil bath (60 °C) for 8 h. The solution is then cooled to room temperature, evaporated under reduced pressure, diluted with ethyl acetate, washed with a saturated aqueous solution of NaCl, dried over Na2SO4, filtered and evaporated under reduced pressure. The crude product is purified by silica gel column chromatography to afford the corresponding product (166.7 mg, Y. 88 %).
In a dry 25 mL round-bottom flask, thiophene (0.5 mmol, 1 eq.), NFSI (0.6 mmol, 1.2 eq.) and CuI (5 mol%) are dissolved in DCE (3 mL), the resulting mixture is put into a preheated oil bath (60 °C) for 8 h. The solution is then cooled to room temperature, evaporated under reduced pressure, diluted with ethyl acetate, washed with a saturated aqueous solution of NaCl, dried over Na2SO4, filtered and evaporated under reduced pressure. The crude product is purified by silica gel column chromatography to afford the corresponding product (166.7 mg, Y. 88 %).
References
Application
Synthesis of Stereoseletive 1-Indanone Derivatives
Reference
PubMed Litterature
Articles de produit
[Research Articles] An Enantioselective Fluorination of α-Branched Aldehydes Using Newly Developed Chiral Amine Catalyst[Research Articles] Copper-catalyzed Direct Amidation of Heterocycles with N-Fluorobenzenesulfonimide
[TCI Practical Example] One-Pot Palladium-Catalyzed Fluorosulfonylation of an Aryl Bromide Using DABSO and NFSI
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