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CAS RN: 60-54-8 | Product Number: T3971
Tetracycline
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Purity: >95.0%(T)(HPLC)
Synonyms:
- (4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€29.00
|
8 | 10 |
|
| 25G |
€46.00
|
1 | 1 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3971 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4N__2O__8 = 444.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 60-54-8 |
| Reaxys Registry Number | 2230417 |
| PubChem Substance ID | 468593045 |
| Merck Index (14) | 9196 |
| MDL Number | MFCD00151232 |
Specifications
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 %(calcd. on anh. substance) |
| Water | max. 5.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 164 °C(dec.) |
| Maximum Absorption Wavelength | 357(H2O) nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 231 mg/l 25 °C |
| Solubility (slightly sol. in) | Alcohol |
| Solubility (insoluble in) | Chloroform, Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-481-9 |
| RTECS# | QI8750000 |
Transport Information:
| HS Number | 2941300000 |
Application
DNA aptamer research
Reference
- Single-stranded DNA aptamers specific for antibiotics tetracyclines
Application
Tetracycline: a Broad Spectrum Polyketide Antibiotic and a Selective Reagent Genetically Engineered Cells
Tetracycline is a polyketide antibiotic isolated from Streptomyces genus. Tetracycline has broad activity against Gram-negative bacteria and Gram-positive bacteria, with a few exceptions, such as Pseudomonas aeruginosa and Proteus species. Tetracycline inhibits protein synthesis in susceptible organisms by binding to the A-site on the 50S subunit of a bacterial ribosome. However, tetracycline-resistant bacterial strains appeared soon after its introduction. Tetracycline is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for tetracycline resistance, which is one of the most frequently used selection markers for obtaining transgenic cells. Recently, tetracycline is used for tetracycline-controlled transcriptional activation systems in cells. (The product is for research purpose only.)
References
- Tetracyclines. Antibiotic action, uptake, and resistance mechanisms (a review)
- Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
- The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
- Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution (a review)
- Update on acquired tetracycline resistance genes
- In vivo gene regulation using tetracycline-regulatable systems
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