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Published TCIMAIL newest issue No.197
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CAS RN: 67-30-1 | Product Number: T3730
3,3',5,5'-Tetraiodothyroacetic Acid
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic Acid
- 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€137.00
|
2 | 5 |
|
| 500MG |
€516.00
|
5 | 34 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3730 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__4H__8I__4O__4 = 747.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 67-30-1 |
| Reaxys Registry Number | 2173215 |
| PubChem Substance ID | 468592913 |
| MDL Number | MFCD00055932 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 230 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 200-649-1 |
| RTECS# | CY1585800 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2918999090 |
Application
3,3',5,5'-Tetraiodothyroacetic Acid: A Thyroid Hormone Analogue with Anti-Angiogenesis and Anti-Tumor Growth Effects
3,3',5,5'-Tetraiodothyroacetic acid is a thyroid hormone (L-thyroxine [T0245]) analogue. It is reported that 3,3',5,5'-tetraiodothyroacetic acid acts at a cell surface receptor to block angiogenic and tumor cell proliferation action of thyroid hormones, which have been recently shown to induce tumor growth and angiogenesis. (The product is for research purpose only.)
References
- Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor
- Tetraiodothyroacetic acid (tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid
- Metabolic Effects of Thyroid Hormone Derivatives (a review)
- Determination of levothyroxine and its degradation products in pharmaceutical tablets by HPLC-UV-ICP-MS
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