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CAS RN: 124937-52-6 | Product Number: T3388
Tolterodine L-Tartrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (R)-N,N-Diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine L-Tartrate
- (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol (2R,3R)-2,3-Dihydroxysuccinate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€93.00
|
3 | 8 |
|
| 5G |
€223.00
|
Contact Us | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3388 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__3__1NO·C__4H__6O__6 = 475.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 124937-52-6 |
| Reaxys Registry Number | 8601255 |
| MDL Number | MFCD07771985 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 205.0 to 209.0 °C |
| Specific rotation [a]20/D | +27.0 to +31.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 207 °C |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | SJ7793450 |
Transport Information:
| HS Number | 2922290090 |
Application
Tolterodine L-Tartrate: A Competitive Antagonist of Acetylcholine at Postganglionic Muscarinic Receptors
Tolterodine L-tartrate is a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Tolterodine is metabolized in the liver, resulting in the formation of 5-hydroxymethyl tolterodine (5-HMT), the major pharmacologically active metabolite. Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors. There are reports that urinary bladder contraction is mediated via cholinergic muscarinic receptors. Therefore, in clinical, tolterodine L-tartrate is used for the treatment of urge incontinence and other symptoms of an overactive bladder. (The product is for research purpose only.)
References
- Tolterodine - a new bladder-selective antimuscarinic agent
- Tolterodine - a new bladder-selective muscarinic receptor antagonist: preclinical pharmacological and clinical data (a review)
- Design and synthesis of a fluorescent muscarinic antagonist
- Muscarinic receptors in the bladder: from basic research to therapeutics (a review)
- The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine (a review)
- High performance liquid chromatography-electrospray ionization mass spectrometric determination of tolterodine tartrate in human plasma
Product Documents (Note: Some products will not have analytical charts available.)
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