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Published TCIMAIL newest issue No.197
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CAS RN: 70-00-8 | Product Number: T2511
Trifluorothymidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- α,α,α-Trifluorothymidine
- Trifluridine
- 2'-Deoxy-5-trifluoromethyluridine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€67.00
|
1 | ≥100 |
|
| 1G |
€515.00
|
1 | 22 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | T2511 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__1F__3N__2O__5 = 296.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 70-00-8 |
| Reaxys Registry Number | 568095 |
| PubChem Substance ID | 87560183 |
| Merck Index (14) | 9687 |
| MDL Number | MFCD00006534 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +47.0 to +53.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 189 °C |
| Specific Rotation | 50° (C=1,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| EC Number | 200-722-8 |
| RTECS# | XP2087500 |
Transport Information:
| HS Number | 2940000080 |
Application
CRISPR Genome Editing / Research on regenerative medicine
Reference
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Application
Trifluridine: A Fluorinated Pyrimidine Nucleoside with Anti-Herpesvirus and Antitumor Activities
Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. Thymidylate kinase (TK) is a key enzyme in the synthesis of thymidine-5'-monophosphate [T0845, di-Na salt], an essential precursor for DNA biosynthesis. Trifluridine is incorporated into (virus or tumor) DNA as its triphosphate via phosphorylation by thymidylate kinase (TK), ultimately suppressing DNA replication and inhibiting cell proliferation.1-4) Trifluridine has activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and vaccinia virus.1-3) Recently, a combined antitumor agent TAS-102 (trifluridine with tipiracil, a thymidine phosphorylase inhibitor) has been used in clinical. Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. 4-6) (The product is for research purpose only.)
References
- 1) Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture
- 2) Trifluorothymidine (a review)
- 3) Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections
- 4) Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes
- 5) A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA
- 6) TAS-102, a novel antitumor agent: a review of the mechanism of action
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