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Published TCIMAIL newest issue No.197
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CAS RN: 56553-60-7 | Product Number: S0394
Sodium Triacetoxyborohydride
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Purity: >80.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€45.00
|
12 | ≥100 |
|
| 100G |
€152.00
|
8 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0394 |
| Purity / Analysis Method | >80.0%(T) |
| Molecular Formula / Molecular Weight | C__6H__1__0BNaO__6 = 211.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive |
| CAS RN | 56553-60-7 |
| Reaxys Registry Number | 4047608 |
| PubChem Substance ID | 87575901 |
| Merck Index (14) | 8695 |
| MDL Number | MFCD00012211 |
Specifications
| Appearance | White powder to crystal |
| Purity(NBS Method) | min. 80.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 106 °C |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H318 : Causes serious eye damage. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. H228 : Flammable solid. H260 : In contact with water releases flammable gases which may ignite spontaneously. |
| Precautionary Statements | P273 : Avoid release to the environment. P231 + P232 : Handle and store contents under inert gas. Protect from moisture. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P302 + P335 + P334 : IF ON SKIN: Brush off loose particles from skin. Immerse in cool water. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
Transport Information:
| UN Number | UN3396 |
| Class | 4.3 / 4.1 |
| Packing Group | II |
| HS Number | 2915390090 |
Application
TCI Practical Example: Reductive Amination Reaction Using Sodium Triacetoxyborohydride
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Used Chemicals
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- m-Anisaldehyde [A0478]
- Dimethylamine Hydrochloride
- Sodium Acetate [S0559]
- Acetic Acid [A2035]
- Sodium Triacetoxyborohydride (= NaBH(OAc)3) [S0394]
- THF
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Procedure
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A solution of m-anisaldehyde (1.00 g, 7.34 mmol), dimethylamine hydrochloride (1.20 g, 14.7 mmol), sodium acetate (964 mg, 11.8 mmol) and acetic acid (253 µL, 4.41 mmol) in THF (30 mL) was stirred at 0 °C for 5 minutes and then sodium triacetoxyborohydride (3.42 g, 16.2 mmol) was added to the solution and stirred at room temperature for 1 hour. The reaction was quenched with sat. aq. NaHCO3 and the aqueous layer was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by NH silica gel column chromatography (ethyl acetate:hexane = 0:100 - 10:90) to give 1-(3-methoxyphenyl)-N,N-dimethylmethanamine as a colorless liquid (940 mg, 77% yield).
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
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Analytical Data
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1-(3-Methoxyphenyl)-N,N-dimethylmethanamine
1H NMR (270 MHz,DMSO); δ 7.22 (t, J = 7.8 Hz, 1H), 6.86-6.79 (m, 3H), 3.73 (s, 3H), 3.34 (s, 2H), 2.13 (s, 6H).
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Lead Reference
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- Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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