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CAS RN: 213416-70-7 | Product Number: P3154
PIPER
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Purity: >95.0%(HPLC)
Synonyms:
- 2,9-Bis[2-(piperidin-1-yl)ethyl]anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
€100.00
|
Contact Us | ≥60 |
|
| 25MG |
€350.00
|
Contact Us | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P3154 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__8H__3__6N__4O__4 = 612.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 213416-70-7 |
| Reaxys Registry Number | 9109510 |
| MDL Number | MFCD02179210 |
Specifications
| Appearance | Red to Dark red to Dark purple powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
GHS
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Application
PIPER: A Potent Telomerase Inhibitor
PIPER is a potent telomerase inhibitor used in cancer research. It inhibits human telomerase by binding to G-quadruplex DNA. Cancer cells evade replicative senescence by re-expressing telomerase, which maintains telomere length and thus chromosomal integrity. Therefore, inhibiting telomerase would cause cancer cells to senesce and thus prevent cancer cells from growing indefinitely. (The product is for research use only.)
References
- NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA
- Accelerated Assembly of G-Quadruplex Structures by a Small Molecule
- Inhibition of Unwinding of G-Quadruplex Structures by Sgs1 Helicase in the Presence of N,N‘-Bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, a G-Quadruplex-Interactive Ligand
- Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase
- G-quadruplex DNA: a potential target for anti-cancer drug design (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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