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CAS RN: 88150-62-3 | Product Number: P2406
Phthaloyl Amlodipine
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 4-(2-Chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester
- 3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€55.00
|
1 | 5 |
|
| 5G |
€188.00
|
Contact Us | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2406 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__8H__2__7ClN__2O__7 = 538.98 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 88150-62-3 |
| Reaxys Registry Number | 6026908 |
| PubChem Substance ID | 468592595 |
| MDL Number | MFCD07782096 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 152 °C |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
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Application
An Impure Substance in the Synthesis of Amlodipine Besylate
This product has been reported as an impure substance in the synthesis of amlodipine besylate [A2353] which is a long-acting dihydropyridine-type calcium channel antagonist or blocker (CCB) used for the treatment of hypertension and cardiovascular disease.
References
- Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents
- Sources of impurities - investigation of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[(2-phthalimidoethoxy)methyl]-1,4-dihydropyridine traces formation during the synthesis of amlodipine besylate
- Identification and characterization of potential impurities of amlodipine maleate
- Enantiomeric separation of amlodipine and its two chiral impurities by nano-liquid chromatography and capillary electrochromatography using a chiral stationary phase based on cellulose tris(4-chloro-3-methylphenylcarbamate)
Product Documents (Note: Some products will not have analytical charts available.)
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