Maintenance Notice (4:30 AM - 11:00 AM December 21, 2024): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 103177-37-3 | Product Number: P2115
Pranlukast
×
![]()
×
Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
31,00 €
|
Contact Us | 16 |
|
| 100MG |
101,00 €
|
1 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2115 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__2__3N__5O__4 = 481.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 103177-37-3 |
| Reaxys Registry Number | 6548353 |
| PubChem Substance ID | 253661988 |
| Merck Index (14) | 7710 |
| MDL Number | MFCD00864631 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 14.00 to 15.00 % |
Properties (reference)
| Melting Point | 233 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | CV5647500 |
Transport Information:
| HS Number | 2934999090 |
Application
Pranlukast: A Cysteinyl Leukotriene (Cys-LT) Receptor Antagonist
Pranlukast (ONO-1078) is a selective and competitive antagonist of the cysteinyl leukotriene receptor (Cys-LTR). Cysteinyl leukotrienes (Cys-LTs) LTC4, LTD4 and LTE4 are potent proinflammatory mediators derived from arachidonic acid [A0781] through the 5-lypoxigenase (5-LO) pathway. Cys-LTs induce pathophysiological responses such as potent bronchoconstriction, mucus secretion, mucosal edema, vascular hyperpermeability and eosinophil infiltration. Hence, Cys-LTs are important mediators of allergy and inflammation. (The product is for research purpose only.)
References
- Pranlukast, a cysteinyl leukotriene receptor antagonist, attenuates allergen-induced early- and late-phase bronchoconstriction and airway hyperresponsiveness in asthmatic subjects
- Characterization of the human cysteinyl leukotriene CysLT1 receptor
- Determination of pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKTTM online solid-phase extraction
- Pranlukast: A review of its use in the management of asthma
- Antileukotriene drugs: clinical application, effectiveness and safety (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.