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CAS RN: 548472-68-0 | Product Number: N1195
Nutlin-3
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Purity: >95.0%(HPLC)
Synonyms:
- rel-4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
101,00 €
|
Contact Us | 17 |
|
| 50MG |
347,00 €
|
Contact Us | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1195 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__0H__3__0Cl__2N__4O__4 = 581.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 548472-68-0 |
| PubChem Substance ID | 468592509 |
| MDL Number | MFCD07784509 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation | -1.0 to +1.0 deg(C=0.2, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
Paraptosis research
Reference
- Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis
- In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
- Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
- Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy (a review)
- Recent advances in the therapeutic perspectives of nutlin-3 (a review)
Application
Nutilin-3: A Small-Molecule Inhibitor of MDM2-P53 Protein-Protein Interaction
Tumor suppress protein p53 is an attractive target for cancer research because it can be functionally activated to eradicate tumors. Mouse double minute 2 homolog (MDM2) is a protein found in many human tumors, and binds the p53 with high affinity and negative modulates p53 transcriptional activity and stability. Nutilin-3 is a small-molecule inhibitor of MDM2-p53 protein-protein interaction. Nutilin-3 binds MDM2 in the p53-binding pocket and activate the p53 pathway in tumor cells, leading to cell cycle arrest, apoptosis, and growth inhibition of tumor cells. (The product is for research purpose only.)
References
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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