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CAS RN: 63675-72-9 | Product Number: N0900
Nisoldipine
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester
- Isobutyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
62,00 €
|
1 | 1 |
|
| 5G |
213,00 €
|
1 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0900 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4N__2O__6 = 388.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 63675-72-9 |
| Reaxys Registry Number | 454188 |
| PubChem Substance ID | 160871273 |
| Merck Index (14) | 6565 |
| MDL Number | MFCD00478055 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 148.0 to 154.0 °C |
Properties (reference)
| Melting Point | 153 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| EC Number | 264-407-7 |
| RTECS# | US7975600 |
Transport Information:
| HS Number | 2933399990 |
Application
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，
Nisoldipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nisoldipine have a longer duration of action. Nisoldipine is mainly metabolized by CYP3A4 in the liver. In addition, nisoldipine coat-core (CC) has been developed extended-release formulation that provides sustained 24-h blood pressure control. (The product is for research purpose only.)
References
- Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists
- Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine
- Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series
- Clinical pharmacokinetics of nisoldipine coat-core (a review)
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