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CAS RN: 75530-68-6 | Product Number: N0899
Nilvadipine
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Purity: >95.0%(N)
Synonyms:
- 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester
- 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€90.00
|
1 | 1 |
|
| 5G |
€301.00
|
6 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0899 |
| Purity / Analysis Method | >95.0%(N) |
| Molecular Formula / Molecular Weight | C__1__9H__1__9N__3O__6 = 385.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 75530-68-6 |
| Reaxys Registry Number | 3572609 |
| PubChem Substance ID | 135727167 |
| Merck Index (14) | 6545 |
| MDL Number | MFCD00867065 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Melting point | 149.0 to 153.0 °C |
Properties (reference)
| Melting Point | 151 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | US7968300 |
Transport Information:
| HS Number | 2933399990 |
Application
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，ニルバジピン
Nilvadipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nilvadipine have a longer duration of action and a greater vasodilatory effect. Nilvadipine is mainly metabolized by CYP3A4 in the liver. Nilvadipine is a poorly water soluble agent, and its solid dispersions have been developed to the solubility. (The product is for research purpose only.)
References
- Effects of nilvadipine on the cardiovascular system in experimental animals
- Effects of nilvadipine, a new calcium entry blocker, on systemic blood pressure, cardiac hypertrophy and venous distensibility in spontaneously hypertensive rats
- Nilvadipine: profile of a new calcium antagonist. An overview
- Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions
- Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropyl methyl cellulose
- Stability study of nilvadipine in bulk drug and pharmaceutical capsules by high performance liquid chromatography
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