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CAS RN: 6964-62-1 | Product Number: M2390
NSC 66811
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Purity: >98.0%(GC)
Synonyms:
- 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
- 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
124,00 €
|
Contact Us | 8 |
|
| 100MG |
374,00 €
|
Contact Us | 28 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2390 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__0N__2O = 340.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 6964-62-1 |
| Reaxys Registry Number | 303275 |
| PubChem Substance ID | 354335381 |
| MDL Number | MFCD08823776 |
Specifications
| Appearance | White to Amber to Dark green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 143.0 to 147.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 145 °C |
| Maximum Absorption Wavelength | 250(EtOH) nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2933499090 |
Application
NSC 66811: An Inhibitor of MDM2-P53 Protein-Protein Interaction
NSC 66811 is an inhibitor of the murine double minute 2 (MDM2)-p53 protein-protein interaction. MDM2 protein is an oncogenic one, and p53 is a tumor suppressor protein. Reportedly, the p53 is inactivated in many cancer cells through mutations or by its interaction with MDM2 protein. Therefore, recently it is considered that blocking the MDM2-p53 interaction is a novel anticancer strategy. (The product is for research purpose only.)
References
- Unleashing p53 (a review)
- Discovery of a Nanomolar Inhibitor of the Human Murine Double Minute 2 (MDM2)-p53 Interaction through an Integrated, Virtual Database Screening Strategy
- Case Study: Discovery of Inhibitors of the MDM2-p53 Protein-Protein Interaction
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