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Published TCIMAIL newest issue No.197
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CAS RN: 224177-60-0 | Product Number: I1090
Siramesine Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]-3H-spiro[isobenzofuran-1,4'-piperidine] Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
€41.00
|
Contact Us | 24 |
|
| 25MG |
€158.00
|
Contact Us | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I1090 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__0H__3__1FN__2O·HCl = 491.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 224177-60-0 |
| Reaxys Registry Number | 14640899 |
| PubChem Substance ID | 468592089 |
| MDL Number | MFCD28144522 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 223.0 to 227.0 °C |
| Elemental analysis(Nitrogen) | gt. 5.20 to 5.80 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 225 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
Siramesine: A σ2 Opioid Receptor Agonist
Siramesine (Lu 28-179) is a σ2 opioid receptor agonist and was first developed as an agent for the treatment of anxiety.1) It was well tolerated and non-toxic in humans but the effect was not satisfactory.2) However, after the development stopped, it has been reported that siramesine induces the death of cancer cells in vitro by destabilizing lysosomes.3-6) (The product is for research purpose only.)
References
- 1) The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents
- 2) Siramesine H Lundbeck
- 3) Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress
- 4) Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing Siramesine
- 5) Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation
- 6) Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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