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Published TCIMAIL newest issue No.197
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CAS RN: 53-86-1 | Product Number: I0655
Indomethacin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic Acid
- Indometacin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€45.00
|
3 | ≥100 |
|
| 100G |
€121.00
|
3 | ≥40 |
|
| 500G |
€387.00
|
4 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0655 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__6ClNO__4 = 357.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 53-86-1 |
| Reaxys Registry Number | 497341 |
| PubChem Substance ID | 87561687 |
| Merck Index (14) | 4968 |
| MDL Number | MFCD00057095 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 158.0 to 162.0 °C |
| Solubility in hot Methanol | almost transparency |
Properties (reference)
| Melting Point | 160 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.937 mg/l 25 °C |
| Solubility (soluble in) | Chloroform, Ether, Acetone, Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 200-186-5 |
| RTECS# | NL3500000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2933998090 |
Application
Reagent for gastropathy (gastric mucosal injury) model
References
- Oxidative stress involvement and gene expression in indomethacin-induced gastropathy
- Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury
- Y. Naito, T. Yoshikawa, N. Yoshida, M. Kondo, Dig. Dis. Sci. 1998, 43, 30S.
- Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
Application
Studies on Inhibition of Cyclooxygenase (COX)
References
- A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
- NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2
- Inducible cyclooxygenase may have anti-inflammatory properties
- Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
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Articles/Brochures
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