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CAS RN: 333717-40-1 | Product Number: E1306
O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium Hexafluorophosphate
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![O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium Hexafluorophosphate](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium Hexafluorophosphate")
Purity: >98.0%(HPLC)(N)
Synonyms:
- HOTU
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€20.00
|
1 | 11 |
|
| 5G |
€67.00
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1306 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__0H__1__7F__6N__4O__3P = 386.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 333717-40-1 |
| Reaxys Registry Number | 20028743 |
| PubChem Substance ID | 354335078 |
| MDL Number | MFCD01862832 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 129.0 to 133.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 132 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| HS Number | 2928009090 |
Application
Condensing Agent with Less Epimerization
Experimental procedure: HOTU (0.25 mmol) is added to a mixture of Cbz-Phe-OH (0.25 mmol), H-Ala-OCH3·HCl (0.25 mmol) and N-methylmorpholine (0.75 mmol) in dry acetonitrile (5 mL) at 0 °C. The reaction mixture is stirred at the same temperature for 1 h and then at room temperature for 2 h. EtOAc (50 mL) is added and the mixture is subsequently washed with 10% aqueous HCl (v/v), saturated aqueous Na2CO3 and saturated aqueous NaCl solution (2 × 10 mL). Finally, the organic solvent is dried with anhydrous Na2SO4, filtered, and the solvent is removed under reduced pressure. The gummy residue is dried under vacuum to obtain 1 (> 99% yield, DL < 1%).
References
- Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis
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