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Published TCIMAIL newest issue No.197
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CAS RN: 301305-73-7 | Product Number: D5275
TCS 359
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Purity: >98.0%(HPLC)
Synonyms:
- 2-(3,4-Dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
- FLT-3 Inhibitor
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€146.00
|
1 | 5 |
|
| 100MG |
€445.00
|
1 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5275 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0N__2O__4S = 360.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 301305-73-7 |
| Reaxys Registry Number | 10482751 |
| PubChem Substance ID | 354334725 |
| MDL Number | MFCD00617269 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 7.30 to 8.30 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
A Potent Inhibitor of Fms - Like Tyrosine Kinase 3 (FLT3)
It is reported that this compound exhibits potent inhibitory activity against the Fms - Like Tyrosine Kinase 3 (FLT3).1) For your information, FLT3 belongs to class III receptor tyrosine kinase family, and expresses on most acute leukemia cells. Therefore, several potent FLT3 inhibitors have been developed in recent years.2)
References
- 1)Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3
- 2)Quantifying the structural requirements for designing newer FLT3 inhibitors
PubMed Literature
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