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Published TCIMAIL newest issue No.197
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CAS RN: 430-67-1 | Product Number: D4758
2,2-Difluoroethylamine
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Purity: >98.0%(GC)(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
18,00 €
|
Contact Us | ≥80 |
|
| 5G |
56,00 €
|
3 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4758 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2H__5F__2N = 81.07 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 430-67-1 |
| Reaxys Registry Number | 1731615 |
| PubChem Substance ID | 253661046 |
| MDL Number | MFCD00798137 |
Specifications
| Appearance | Colorless to Yellow clear liquid |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 68 °C |
| Flash point | -34 °C |
| Specific Gravity (20/20) | 1.17 |
| Refractive Index | 1.34 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H225 : Highly flammable liquid and vapour. |
| Precautionary Statements | P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
Transport Information:
| UN Number | UN2733 |
| Class | 3 / 8 |
| Packing Group | II |
| HS Number | 2914790090 |
Application
Reagents for Difluoromethylation (Precursor to difluoromethyl diazomethane)
Typical Procedure:
To a stirred solution of 2,2-difluoroethylamine (193 mg, 2.38 mmol, 2.0 eq.) in CHCl3 (20 mL), tert-butyl nitrite (294 mg, 2.86 mmol, 2.4 eq.) and acetic acid (28 mg, 0.48 mmol, 0.4 eq.) are added. The solution is heated at reflux whereas the mixture becomes deeply yellow. After 10 min, the heating is stopped, and the reaction mixture is cooled down to a room temperature by external water bath. Methyl propiolate (100 mg, 1.19 mmol, 1.0 eq.) is added at once. The reaction mixture is left at room temperature for 24 h. The solvent is evaporated under vacuum. The formed oily residue is purified by column chromatography on silica gel using hexane-EtOAc (2:1) as an eluent, to afford the pure product (159 mg, 0.90 mmol, 76% yield) as a colorless solid.
To a stirred solution of 2,2-difluoroethylamine (193 mg, 2.38 mmol, 2.0 eq.) in CHCl3 (20 mL), tert-butyl nitrite (294 mg, 2.86 mmol, 2.4 eq.) and acetic acid (28 mg, 0.48 mmol, 0.4 eq.) are added. The solution is heated at reflux whereas the mixture becomes deeply yellow. After 10 min, the heating is stopped, and the reaction mixture is cooled down to a room temperature by external water bath. Methyl propiolate (100 mg, 1.19 mmol, 1.0 eq.) is added at once. The reaction mixture is left at room temperature for 24 h. The solvent is evaporated under vacuum. The formed oily residue is purified by column chromatography on silica gel using hexane-EtOAc (2:1) as an eluent, to afford the pure product (159 mg, 0.90 mmol, 76% yield) as a colorless solid.
References
- In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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