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CAS RN: 569-57-3 | Product Number: C3869
Chlorotrianisene
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- 4,4',4''-(2-Chloroethene-1,1,2-triyl)tris(methoxybenzene)
- Chlorotris(p-methoxyphenyl)ethylene
- Tri-p-anisylchloroethylene
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
170,00 €
|
1 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3869 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__3H__2__1ClO__3 = 380.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 569-57-3 |
| Reaxys Registry Number | 1891845 |
| MDL Number | MFCD00048044 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 114.0 to 118.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 116 °C |
| Solubility (soluble in) | Ether, Acetone |
GHS
Related Laws:
| EC Number | 209-318-6 |
| RTECS# | KV0600000 |
Transport Information:
| HS Number | 2909309090 |
Application
Chlorotrianisene: An Estrogen Receptor Modulator
Chlorotrianisene is a synthetic non-steroidal estrogen and an estrogen receptor modulator (agonist/antagonist). It exhibits little or no binding to the uterine estrogen receptor in vitro, but demonstrates potent estrogenic activity in vivo, indicating that it is a prodrug (pro-estrogen/pro-antiestrogen). (The product is for research purpose only.)
References
- Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells
- P. C. Ruenitz, S. A. Moore, K. S. Kraft, C. S. Bourne, J. Steroid Biochem. Mol. Biol. 1997, 63, 203.
- Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor
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