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CAS RN: 3895-92-9 | Product Number: C3584
Chelerythrine Chloride
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Purity: >97.0%(HPLC)
Synonyms:
- 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium Chloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€121.00
|
1 | 9 |
|
| 100MG |
€399.00
|
6 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C3584 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__1__8ClNO__4 = 383.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3895-92-9 |
| Reaxys Registry Number | 3898541 |
| MDL Number | MFCD00060717 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Water | max. 12.0 % |
Properties (reference)
| Melting Point | 195 °C |
| Maximum Absorption Wavelength | 320(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 223-444-9 |
| RTECS# | FL9200000 |
Transport Information:
| HS Number | 2939799090 |
Application
Chelerythrine Chloride: A Cell-Permeable Protein Kinase C
Chelerythrine chloride is a benzophenanthridine alkaloid isolated from roots of F. zanthoxyloides.1) Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase.2) It has been reported that chelerythrine chloride induces apoptotic cell death of cancer cells.3-6)
References
- 1) Antimicrobial alkaloids from a Nigerian chewing stick (Fagara zanthoxyloides)
- 2) Chelerythrine is a potent and specific inhibitor of protein kinase C
- 3) βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle
- 4) Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation
- 5) In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo
- 6) Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 Cell
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