Published TCIMAIL newest issue No.196
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 329196-48-7 | Product Number: A3537
SANT-2
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
- N-[3-[1H-Benzo[d]imidazol-2-yl]-4-chlorophenyl]-3,4,5-triethoxybenzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€250.00
|
Contact Us | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3537 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__6ClN__3O__4 = 479.96 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 329196-48-7 |
| Reaxys Registry Number | 12773727 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 215.0 to 219.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 217 °C |
GHS
Related Laws:
Transport Information:
Application
SANT-2: A Smoothened (Smo) Receptor Antagonist
SANT-2 is a Smoothened (Smo) receptor antagonist. Smo, a Class Frizzled (Class F) G protein-coupled receptors, mediates Hedgehog (Hh) signaling that controls growth, cell fate decisions, and morphogenesis during development. There are reports that SANT-2 inhibits Smo activity and Hh signaling induced by an N-terminal fragment of sonic hedgehog (Shh). In addition, SANT-2 has been used in cancer research, as aberrant activation of the Hh signaling pathway has been implicated in a variety of cancers.
References
- Small molecule modulation of Smoothened activity
- J. K. Chen, J. Taipale, K. E. Young, T. Maiti, P. A. Beachy, Proc. Natl. Acad. Sci. 2002, 99, 14071.
- Evidence for allosteric interactions of antagonist binding to the Smoothened receptor
- Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.