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CAS RN: 3768-18-1 | Product Number: A3535
N4-Acetylcytidine
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Purity: >95.0%(T)(HPLC)
Synonyms:
- N-(1,2-Dihydro-2-oxo-1-β-D-ribofuranosyl-4-pyrimidinyl)acetamide
- N-[1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]acetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€ 45,00
|
Contact Us | 26 |
|
| 25G |
€ 155,00
|
Contact Us | 22 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3535 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__5N__3O__6 = 285.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 3768-18-1 |
| Reaxys Registry Number | 624343 |
| MDL Number | MFCD00006540 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation | +55.0 to +59.0 deg(C=1, water) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 209 °C |
GHS
Related Laws:
| EC Number | 223-195-6 |
Transport Information:
| HS Number | 2934999099 |
Application
N4-Acetylcytidine: A Highly Conserved Modified RNA nucleoside
N4-Acetylcytidine (ac4C) is a highly conserved modified RNA nucleoside whose formation is catalyzed by the N-acetyltransferase 10 (NAT10). Recent studies have discovered that N4-acetylcytidine is a prevalent mRNA modification in eukaryotes and has roles in cell viability and development through these effects on RNA as follows; translation efficiency, mRNA stability, codon recognition, and tRNA structure, thereby opening up an emerging research field known as epitranscriptomics.
References
- Acetylation of Cytidine in mRNA Promotes Translation Efficiency
- The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review
- The emerging role of RNA modifications in the regulation of mRNA stability (a review)
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