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Published TCIMAIL newest issue No.197
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CAS RN: 757251-39-1 | Product Number: A2979
4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
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Purity: >98.0%(HPLC)
Synonyms:
- 4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
25,00 €
|
1 | 23 |
|
| 1G |
86,00 €
|
1 | 18 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2979 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__2FN__3O__2 = 261.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 757251-39-1 |
| Reaxys Registry Number | 12196700 |
| PubChem Substance ID | 354333908 |
| MDL Number | MFCD09033852 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 141.0 to 145.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 143 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
A Key Synthetic Intermediate of Regorafenib
This product is used for a key synthetic intermediate of regorafenib [R0142] which is a multikinase inhibitor of tumour angiogenesis, oncogenesis and the tumour microenvironment.
References
- Fluoro substituted omega-carboxyaryl diphenyl urea for treatment of raf, VEGFR, PDGFR, p38 and flt-3 kinase-mediated diseases
- J. Dumas, S. Boyer, B. Riedl, S. Wilhelm, World Intellectual Property Organization, WO/2005/009961 A2.
- An efficient and high-yielding protocol for the production of Regorafenib via a new synthetic strategy
- A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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