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Published TCIMAIL newest issue No.197
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Williamson Ether Synthesis
The Williamson ether synthesis is an old, but still frequently encountered organic reaction, which provides ether products most often from alcohols and alkyl halides. Alkoxides, derived from alcohols and bases such as sodium hydride or generated in situ, and alkyl halides can react through SN2 type mechanisms to give a variety of ether products. The reactivity is generally dependent on reaction the scope of the pertinent SN2 reaction, with sterics being the dominant presiding factor.
- Reagents:
- Alcohols, Alkoxides
- Reactants:
- Alkyl halides
- Products:
- Ethers
- Scheme:
-
- Original literature:
-
- XLV. Theory of ætherification
- Review literature:
-
- Metallic Salts of Alcohols and Alcohol Analogs.
Related category page
- Halogenated Alkyl [Non-Heterocyclic Fluorinated Building Blocks]
- Halogenated Hydrocarbons (Fluorides expected) [Non-Heterocyclic Building Blocks]
- Alcohols [Chiral Non-Heterocyclic Building Blocks]
- Alcohols [Non-Heterocyclic Fluorinated Building Blocks]
- Alcohols [Non-Heterocyclic Building Blocks]
- Phenols [Non-Heterocyclic Fluorinated Building Blocks]
- Phenols [Non-Heterocyclic Building Blocks]