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α-Galactosyl Ceramide (α-GalCer) is an artificial glycolipid which has been developed based on the sphingolipid extracted from the sea sponge, Agelas mauritianus.1,2,3) Work conducted by Prof. Taniguchi demonstrated that α-GalCer forms a complex with the CD1d antigen present on cell surfaces.4,5) This complexing results in strong NKT (Natural Killer T) cell activation causing high levels of cytokine production. The NKT cells bare features of both of NK cells and T cells.6,7)
Since α-GalCer is related to immune functions, it is used in disease research on cancer, atopic dermatitis and asthma and also is used as an adjuvant for experiment and research. Moreover, a synthetic intermediate ofα-GalCer is required in synthetic research of analogs containing different functional groups such as unsaturation and aromatic groups on the ceramide moiety which can increase biological activity of α-GalCer.8)
TCI can provide large amount of α-GalCer and its intermediates synthesized in our facilities. Additionally, we can offer highly pure α-GalCer for use as a standard and other applications.
Advantages
- High purity, fully synthetic product available for scale-up
- We can accept production consultation of GMP.
References
- 1) Structure-Activity Relationship of α-Galactosylceramides against B16-Bearing Mice
- 2) Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus
- 3) Agelasphins, novel α-galactosylceramides from the marine sponge Agelas mauritianus
- 4) CD1d-Restricted and TCR-Mediated Activation of Vα14 NKT Cells by Glycosylceramides
- 5) Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells
- 6) The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response
- 7) Predominant expression of invariant Vα14+ TCR α chain in NK1.1+ T cell populations
- 8) Fifteen Years since the Development of KRN7000 – Structure-Activity Relationship Studies on Novel Glycosphingolipids Which Stimulate Natural Killer T Cells
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