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CAS RN: 183266-61-7 | Product Number: T3174
(Trifluoroacetyl)benzotriazole (mixture of 1H- and 2H- isomers)
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€53.00
|
1 | 4 |
|
| 5G |
€186.00
|
1 | 6 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3174 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__4F__3N__3O = 215.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 183266-61-7 |
| Reaxys Registry Number | 7707570 |
| PubChem Substance ID | 253660844 |
| MDL Number | MFCD00593044 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 67.0 to 71.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 69 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
Trifluoroacetylation of Amines
[Experimental procedure]
A solution of 2-phenylethylamine (0.61 g, 5.0 mmol) and (trifluoroacetyl)benzotriazole (1.18 g, 5.5 mmol) in THF (dried, 20 mL) is stirred at room temperature for 4 hours. Then the mixture is diluted with ethyl acetate (20 mL) and washed with aqueous 2 N sodium hydroxide solution (2 x 15 mL). The aqueous layers are extracted with ethyl acetate (20 mL). The combined organic layers are dried over sodium sulfate. After the removal of organic solvent, the crude product is obtained in quantitative yield.
A solution of 2-phenylethylamine (0.61 g, 5.0 mmol) and (trifluoroacetyl)benzotriazole (1.18 g, 5.5 mmol) in THF (dried, 20 mL) is stirred at room temperature for 4 hours. Then the mixture is diluted with ethyl acetate (20 mL) and washed with aqueous 2 N sodium hydroxide solution (2 x 15 mL). The aqueous layers are extracted with ethyl acetate (20 mL). The combined organic layers are dried over sodium sulfate. After the removal of organic solvent, the crude product is obtained in quantitative yield.
References
- (Trifluoroacetyl)benzotriazole: A Convenient Trifluoroacetylating Reagent
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