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Published TCIMAIL newest issue No.197
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CAS RN: 58-46-8 | Product Number: T2839
Tetrabenazine
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Purity: >99.0%(T)(HPLC)
Synonyms:
- 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
91,00 €
|
5 | 13 |
|
| 1G |
313,00 €
|
2 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2839 |
| Purity / Analysis Method | >99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__7NO__3 = 317.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 58-46-8 |
| Reaxys Registry Number | 40090 |
| PubChem Substance ID | 160871211 |
| Merck Index (14) | 9182 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 124.0 to 130.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 127 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-383-6 |
| RTECS# | DK2275000 |
Transport Information:
| HS Number | 2933998090 |
Application
Tetrabenazine: A Reversible Inhibitor of the Vesicular Monoamine Transporter Type 2 (VMAT2)
Tetrabenazine is a reversible selective inhibitor of the vesicular monoamine transporter type 2 (VMAT2) resulting in decreased uptake of monoamines into synaptic vesicles, breaking down of monoamines by monoamine oxidase (MAO) and depletion of monoamine stores. Therefore, tetrabenazine works as a depletor of monoamines (such as dopamine [A0305], serotonin [S0370], norepinephrine [A0906], and histamine [H0146]) from nerve terminals. Tetrabenazine is metabolitzed by carbonyl reductase to the initial active metabolite dihydrotetrabenazine (HTBZ), a mixture of α-HTBZ and β-HTBZ. HTBZ also inhibits the VMAT2. Although the precise mechanism is unknown, tetrabenazine is effective in treating chorea (Huntington’s disease). In addition, reserpine [R0007] inhibits VMAT. (The product is for research purpose only.)
References
- Tetrabenazine-induced depletion of brain monoamines: Characterization and interaction with selected antidepressants
- Pharmacokinetics of tetrabenazine and its major metabolite in man and rat
- Absolute configuration of (+)-α-dihydrotetrabenazine, an active metabolite of tetrabenazine
- Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A
- Tetrabenazine for the Treatment of Hyperkinetic Movement Disorders: A Review of the Literature
- Development and validation of stability indicating RP-HPLC method for the estimation of tetrabenazine in bulk and pharmaceutical dosage form
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