Published TCIMAIL newest issue No.197
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CAS RN: 4083-64-1 | Product Number: T0998
p-Toluenesulfonyl Isocyanate
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Purity: >95.0%(T)
Synonyms:
- Tosyl Isocyanate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€16.00
|
28 | ≥100 |
|
| 100G |
€35.00
|
1 | ≥40 |
|
| 500G |
€110.00
|
3 | 1 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
[Handling Notes]
This product may deposit some white solids during storage.
Please use all of the material as soon as possible upon receiving it.
| Product Number | T0998 |
| Purity / Analysis Method | >95.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__7NO__3S = 197.21 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 4083-64-1 |
| Reaxys Registry Number | 391287 |
| PubChem Substance ID | 87576806 |
| SDBS (AIST Spectral DB) | 13756 |
| MDL Number | MFCD00002030 |
Specifications
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(Neutralization titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | -2 °C |
| Boiling Point | 130 °C/6 mmHg |
| Flash point | 145 °C |
| Specific Gravity (20/20) | 1.30 |
| Refractive Index | 1.53 |
| Solubility (soluble in) | Acetone, Toluene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H332 : Harmful if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 : May cause respiratory irritation. |
| Precautionary Statements | P261 : Avoid breathing mist or vapours. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| EC Number | 223-810-8 |
| RTECS# | DB9032000 |
Transport Information:
| HS Number | 2935909099 |
Application
Derivatization Reagent of Hydroxyl Group for LC-MS
References
- p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma
- Development and validation of an LC?ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma
Application
A Novel Hydroxy Protecting Group: Sulfonylcarbamate Group
Typical Procedure:
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
References
Application
Synthesis of N-Acylsulfonamides
Reference
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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