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Published TCIMAIL newest issue No.200
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CAS RN: 224452-66-8 | Product Number: R0282
Retapamulin
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- SB-275833
- (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-[[(1R,3s,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]thio]acetate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
€115.00
|
Contact Us | 21 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | R0282 |
Purity / Analysis Method 
|
>98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__3__0H__4__7NO__4S = 517.77 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 224452-66-8 |
| Reaxys Registry Number | 10626337 |
| MDL Number | MFCD11045316 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | AI8976800 |
Transport Information:
| HS Number | 2941900000 |
Application
Retapamulin: A Semi-Synthetic Derivative of the Naturally Occurring Antibiotic Pleuromutilin
Retapamulin (SB-275833) is a semi-synthetic derivative of the naturally occurring pleuromutilin produced by Pleurotus mutilus, an edible mushroom. Retapamulin inhibits bacterial protein biosynthesis in Staphylococcus aureus organisms by inhibiting translation and formation of the 50S ribosomal subunit in cells. (The product is for research use only.)
References
- Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant Gram-positive cocci
- Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells
- Retapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infections
- Efficient Antibacterial Agents: A Review of the Synthesis, Biological Evaluation and Mechanism of Pleuromutilin Derivatives (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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