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CAS RN: 20554-84-1 | Product Number: P1982
Parthenolide
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Purity: >97.0%(HPLC)
Synonyms:
- 4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic Acid γ-Lactone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
48,00 €
|
1 | 30 |
|
| 100MG |
142,00 €
|
1 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1982 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__0O__3 = 248.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 20554-84-1 |
| Reaxys Registry Number | 17582 |
| PubChem Substance ID | 135727274 |
| Merck Index (14) | 7048 |
| MDL Number | MFCD00134592 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Specific rotation [a]20/D | -81.0 to -86.0 deg(C=1, CHCl3) |
Properties (reference)
| Melting Point | 115 °C |
| Specific Rotation | -84° (C=1,CHCl3) |
| Solubility (soluble in) | Chloroform |
GHS
Related Laws:
| RTECS# | LY4220000 |
Transport Information:
| HS Number | 2932209090 |
Application
Type IV secretion system (T4SS) research
Reference
- Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila
Application
Parthenolide: A Sesquiterpene Lactone with Potent Anticancer and Anti-Inflammatory Activities
Parthenolide, a sesquiterpene lactone, is originally isolated from the shoots of feverfew (Tanacetum parthenium) which is a traditional medical plant used commonly to prevent migraine headaches. Parthenolide has been reported to show potent anticancer and anti-inflammatory activities. For example, parthenolide inhibits the transcription factor NF-κB, and induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. (The product is for research purpose only.)
References
- The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex
- The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
- The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
- Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities (a review)
- Parthenolide: from plant shoots to cancer roots (a review)
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