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CAS RN: 33069-62-4 | Product Number: P1632
Paclitaxel
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
89,00 €
|
27 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1632 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__7H__5__1NO__1__4 = 853.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 33069-62-4 |
| Reaxys Registry Number | 4290260 |
| PubChem Substance ID | 87558555 |
| MDL Number | MFCD00869953 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | -49.0 to -54.0 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 216 °C |
| Specific Rotation | -52° (C=1,MeOH) |
| Maximum Absorption Wavelength | 227(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | DA8340750 |
Transport Information:
| HS Number | 2932990090 |
Application
Paraptosis research
Reference
- Taxol Induces Paraptosis Independent of Both Protein Synthesis and MAPK Pathway
- Taxol and taxotere: discovery, chemistry, and structure-activity relationships
- Microtubules as a target for anticancer drugs
- Paclitaxel-induced cell death: where the cell cycle and apoptosis come together
- Mechanism of action of antitumor drugs that interact with microtubules and tubulin
- A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
- R. C. Polomano, A. J. Mannes, U. S. Clark, G. J. Bennett, Pain 2001, 94, 293.
- Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
- Cremophor EL the drawbacks and advantages of vehicle selection for drug formulation
- Paclitaxel and its formulations
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
Application
Paclitaxel: An Antimicrotubule Agent
Paclitaxel is an antimicrotubule agent. It was initially extracted from the bark of Taxus brevifolia, and at present, it is semi-synthesized from 10-deacetylbaccatin III [D4148] isolated from the yew tree (Genera Taxus). The tubulin has two subunits, α and β, which are arranged in a cylindrical pattern to form a hollow protein. Paclitaxel specifically binds to the β-tubulin subunit of microtubules, promotes and stabilizes microtubule polymerization. As the result, it influences the formation and function of spindles (made up of microtubules) during mitosis (M phase), and also affects the function of microtubules in the cell. It is thought to be cytotoxic by arresting the cell cycle during M phase. For your reference, [B4127] and [H1656] are synthetic Intermediates of the side chains of docetaxel [D4102] and paclitaxel. (The product is for research purpose only.)
References
Application
Reagent for pain model
References
Application
Reviews on Formulations and Drug Delivery Systems (DDS) of Paclitaxel
References
PubMed Literature
Articles/Brochures
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