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Published TCIMAIL newest issue No.197
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CAS RN: 56391-57-2 | Product Number: N1108
Netilmicin Sulfate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€65.00
|
1 | 3 |
|
| 100MG |
€203.00
|
4 | 4 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1108 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__4__1N__5O__7·2^^1/__2H__2SO__4 = 720.77 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 56391-57-2 |
| Related CAS RN | 56391-56-1 |
| Reaxys Registry Number | 5710471 |
| PubChem Substance ID | 354335742 |
| Merck Index (14) | 6479 |
| MDL Number | MFCD01311715 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Specific rotation [a]20/D | +87.0 ～ +96.0 deg(C=3, water, calcd.on dried substance) |
| Water | max. 15.0 % |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 91° (C=3,H2O,calcd.on dried substance) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 260-147-3 |
| RTECS# | WK2286000 |
Transport Information:
| HS Number | 2941900000 |
Application
Netilmicin Sulfate: An Aminoglycoside Antibiotic with Less Ear and Kidney Toxicity
Netilmicin sulfate, a semisynthetic 1-N-ethyl derivative of sisomicin sulfate [I1049], is an aminoglycoside antibiotic with action similar to gentamicin sulfate [G0383], but less ear and kidney toxicity. Netilmicin is active against most Gram-negative and Gram-positive Staphylococcus, including many gentamicin-resistant strains. Netilmicin interacts with the 30S subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. (The product is for research purpose only.)
References
- Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance
- Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use (a review)
- Determination of netilmicin sulfate by liquid chromatography with pulsed electrochemical detection
- Development and Validation of a RP-HPLC Method for the Estimation of Netilmicin Sulfate and its Related Substances using Charged Aerosol Detection
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