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Published TCIMAIL newest issue No.197
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CAS RN: 91421-42-0 | Product Number: N0822
9-Nitrocamptothecin
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Purity: >98.0%(HPLC)
Synonyms:
- Rubitecan
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€225.00
|
Contact Us | 37 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N0822 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__1__5N__3O__6 = 393.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 91421-42-0 |
| Reaxys Registry Number | 5365063 |
| PubChem Substance ID | 87560509 |
| Merck Index (14) | 8288 |
| MDL Number | MFCD06656294 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +36.0 to +42.0 deg(C=0.4, CHCl3:MeOH=8:2) |
Properties (reference)
| Melting Point | 268 °C |
| Specific Rotation | 39° (C=0.4,CHCl3:MeOH=8:2) |
GHS
Related Laws:
Transport Information:
| HS Number | 2939790090 |
Application
水不溶性のトポイソメラーゼ I阻害剤，9-ニトロカンプトテシン (9-NC)
9-Nitrocamptothecin (9-NC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. Its metabolite is 9-aminocamptothecin [A2063]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.
References
- Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity
- Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin
- Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
- Encapsulation of 9-nitrocamptothecin, a novel anticancer drug, in biodegradable nanoparticles: factorial design, characterization and release kinetics
- The camptothecins (a review)
- Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high- performance liquid chromatography with ultraviolet and fluorescence detection
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