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CAS RN: 126-18-1 | Product Number: M3546
Smilagenin
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- (25R)-5β-Spirostan-3β-ol
- (3β,5β,25R)-Spirostan-3-ol
- (2aR,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€245.00
|
Contact Us | 31 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M3546 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__7H__4__4O__3 = 416.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 126-18-1 |
| Reaxys Registry Number | 91753 |
| MDL Number | MFCD00037845 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC)(CAD) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Specific rotation | -65.0 to -71.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C |
GHS
Related Laws:
| EC Number | 204-775-8 |
Transport Information:
| HS Number | 2932990090 |
Application
Smilagenin: A Steroidal Sapogenin with Neuroprotective and Neuro-Restorative Activities
Smilagenin (PYM50028) is a steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum which are widely used in traditional Chinese medicine for the treatment of neurodegenerative diseases. There are reports that smilagenin improves memory in aged rats by increasing muscarinic receptor subtype 1 (M1) receptor density,1) and has neuroprotective and neuro-restorative potential for the treatment of neurodegenerative diseases, including Alzheimer's and Parkinson's disease.2-4) (The product is for research purpose only.)
References
- 1) Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats
- 2) Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor
- 3) PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease
- 4) Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models
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