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CAS RN: 1769-24-0 | Product Number: M2709
2-Methyl-4(1H)-quinazolinone
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Purity: >98.0%(GC)(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€ 85,00
|
1 | 20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2709 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__9H__8N__2O = 160.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1769-24-0 |
| Reaxys Registry Number | 124603 |
| PubChem Substance ID | 354333543 |
| MDL Number | MFCD01457186 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 238.0 to 242.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 240 °C |
| Maximum Absorption Wavelength | 316 nm (CH__3CN) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 217-189-2 |
| RTECS# | VA3677000 |
Transport Information:
| HS Number | 2933599590 |
Application
2-Methyl-4(1H)-quinazolinone: An Inhibitor of Poly (ADP-Ribose) Polymerase (PARP) Enzymes
Genomic instability is a hallmark of cancer and is often the result of altered DNA repair capabilities in tumor cells. Poly (ADP-ribose) polymerases (PARPs) are enzymes responsible for DNA damage detection and repair factor recruitment. PARP inhibitors are able to interact with the binding site for the PARP cofactor NAD+ and trap PARP on DNA, and induce cell death through replication stress-induced mitotic catastrophe. It has been reported that 2-methyl-4(1H)-quinazolinone is a PARP inhibitor and has neuroprotective effects. (The product is for research use only.)
References
- Production of 2-methyl-4[3H]quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium
- Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase
- Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and Quantitative Structure-Activity Relationship Analysis
- Synthesis and study of new 4-quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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