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Published TCIMAIL newest issue No.197
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CAS RN: 21535-47-7 | Product Number: M2623
Mianserin Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€34.00
|
1 | 20 |
|
| 1G |
€118.00
|
1 | 18 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2623 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0N__2·HCl = 300.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 21535-47-7 |
| Related CAS RN | 24219-97-4 |
| Reaxys Registry Number | 4280594 |
| PubChem Substance ID | 253662317 |
| Merck Index (14) | 6172 |
| MDL Number | MFCD00055072 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 284 °C |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
| Solubility (insoluble in) | Toluene |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 244-426-7 |
| RTECS# | HP8780000 |
Transport Information:
| HS Number | 2933599590 |
Application
Mianserin Hydrochloride: An Antagonist at 5-HT2 and α2-Adrenergic Receptors
Mianserin hydrochloride (GB 94) is a tetracyclic antidepressant with combined serotonergic–noradrenergic mechanism of action. It is an antagonist mainly at 5-HT2 and α2-adrenergic receptors, and increases serotonergic (5HT) [S0370] and noradrenergic (NA) [A0906] neurotransmission. (The product is for research purpose only.)
References
- A comparative study of the effects of selective and non-selective 5-HT2 receptor subtype antagonists in rat and mouse models of anxiety
- Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine (a review)
- Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness
- Mianserin (a review)
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