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Published TCIMAIL newest issue No.197
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CAS RN: 89-25-8 | Product Number: M0687
3-Methyl-1-phenyl-5-pyrazolone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Monopyrazolone
- Edaravone
- MCI-186
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€16.00
|
5 | ≥80 |
|
| 500G |
€44.00
|
2 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M0687 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__0N__2O = 174.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 89-25-8 |
| Reaxys Registry Number | 609575 |
| PubChem Substance ID | 87572698 |
| SDBS (AIST Spectral DB) | 2704 |
| Merck Index (14) | 6713 |
| MDL Number | MFCD00003138 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 128.0 to 131.0 °C |
| Solubility in N,N-DMF | almost transparency |
| Suitability for cyan-analysis | to pass test |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 129 °C |
| Boiling Point | 287 °C/265 mmHg |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Benzene, Alcohol, Chloroform, Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 201-891-0 |
| RTECS# | UQ9625000 |
Transport Information:
| HS Number | 2933199090 |
Application
Edaravone: A Strong Free Radical Scavenger and a Powerful Antioxidant
Edaravone (MCI-186) is a strong free radical scavenger and a powerful antioxidant. There have been many reports describing that free radicals such as hydroxyl radical (·OH) play a major causative role in the development of cerebral vascular disorder resulting from ischaemia. During ischaemia or ischemic reperfusion, the hyperactivity of a metabolic system of arachidonic acid increases the production of free radicals. These free radicals peroxidize unsaturated fatty acid of cell membrane lipids leads to cell membrane injury. Besides, oxidative stress is believed to contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone inhibits lipid peroxidation, and thereby prevents oxidative damage to brain cells or neurons. Consequently, edaravone improves of neurological symptoms, and inhibits the progression of ALS. (The product is for research purpose only.)
References
- High-performance liquid chromatography of reducing carbohydrates as strongly ultraviolet-absorbing and electrochemically sensitive 1-phenyl-3-methyl-5-pyrazolone derivatives
- Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions
- Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model
- Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury (a review)
- Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases
- Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
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