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CAS RN: 160970-54-7 | Product Number: I1128
Silodosin
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Purity: >97.0%(GC)(T)
Synonyms:
- (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy)ethyl]amino]propyl]indoline-7-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
75,00 €
|
Contact Us | 1 |
|
| 1G |
184,00 €
|
Contact Us | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I1128 |
| Purity / Analysis Method | >97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__5H__3__2F__3N__3O__4 = 495.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 160970-54-7 |
| Reaxys Registry Number | 8175841 |
| PubChem Substance ID | 468592113 |
| MDL Number | MFCD00930170 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 105.0 to 109.0 °C |
| Specific rotation | -13.0 to -17.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 107 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol, Dimethylformamide, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NL5994752 |
Transport Information:
| HS Number | 2933998090 |
Application
Silodosin: A Selective Antagonist of α1A-Adrenoceptor
Silodosin (KMD-3213) is a selective antagonist of α1A-adrenoceptor (AR) subtype. This agent selectively binds to α1A-AR, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. Inhibition of the receptor in these tissues can block the sympathetic nerve transmission and cause smooth muscle to relax, resulting in an improvement in urine flow and a reduction in benign prostatic hypertrophy (BPH) symptoms. For your reference, [T3505] is a synthetic intermediate of silodosin. (The product is for research purpose only.)
References
- KMD-3213, a novel, potent, α1a-adrenoceptor-selective antagonist: characterization using recombinant human α1-adrenoceptors and native tissues
- KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat model
- Silodosin, a novel selective α1A -adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia (a review)
- Determination of silodosin in human plasma by liquid chromatography-tandem mass spectrometry
- シロドシン (KMD-3213) のα1-アドレナリン受容体サブタイプ選択性及び臓器特異性
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