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Published TCIMAIL newest issue No.197
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CAS RN: 465-99-6 | Product Number: H1645
Hederagenin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3β,4α-3,23-Dihydroxyolean-12-en-28-oic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€137.00
|
Contact Us | 39 |
|
| 200MG |
€371.00
|
1 | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1645 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__0H__4__8O__4 = 472.71 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 465-99-6 |
| Reaxys Registry Number | 2711855 |
| PubChem Substance ID | 354335220 |
| Merck Index (14) | 4624 |
| MDL Number | MFCD00017385 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +81.0 to +85.0 deg(C=1, Pyridine) |
Properties (reference)
| Melting Point | 334 °C |
| Maximum Absorption Wavelength | 405(H2SO4) nm |
GHS
Related Laws:
| EC Number | 207-369-9 |
Transport Information:
| HS Number | 2918199890 |
Application
Hederagenin: A Pentacyclic Triterpenoid with Many Biological Activities
Hederagenin is a pentacyclic triterpenoid. It is the aglycone part of numerous saponins found in Hedera helix, etc. and found in a variety of traditional medicines and food products. Reportedly, hederagenin and its glycosides (saponins) possess many biological activities such as anti-inflammatory1,2), antitumor3,4), antimutagenic5) and anticomplementary6) activities. Furthermore, hederagenin has been reported as a serotonin, norepinephrine and dopamine reuptake inhibitor.7) (The product is for research purpose only.)
References
- 1)Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi Gaertn
- 2)In vitro antiinflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells
- 3)Hederagenin as a triterpene template for the development of new antitumor compounds
- 4)Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides
- 5)Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus
- 6)In vitro anticomplementary activity of hederagenin saponins isolated from roots of Dipsacus asper
- 7)The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: Serotonin, norepinephrine and dopamine reuptake inhibitor
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