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CAS RN: 747-36-4 | Product Number: H1306
Hydroxychloroquine Sulfate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 7-Chloro-4-[4-[N-ethyl-N-(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline Sulfate
- N4-(7-Chloro-4-quinolyl)-N1-ethyl-N1-(2-hydroxyethyl)-1,4-pentanediamine Sulfate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€45.00
|
2 | ≥100 |
|
| 25G |
€146.00
|
Contact Us | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | H1306 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__8H__2__6ClN__3O·H__2SO__4 = 433.95 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 747-36-4 |
| Related CAS RN | 118-42-3 |
| Reaxys Registry Number | 7242072 |
| PubChem Substance ID | 125307498 |
| SDBS (AIST Spectral DB) | 52824 |
| Merck Index (14) | 4818 |
| MDL Number | MFCD00078203 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 212-019-3 |
| RTECS# | KK3342500 |
Transport Information:
| HS Number | 2933499090 |
Application
Adeno-associated virus vector transduction enhancer
Hydroxychloroquine increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues
Application
Hydroxychloroquine Sulfate: A Derivative of 4-Aminoquinoline with Autophagy Inhibitory, Antimalarial and Anticancer Activities
Hydroxychloroquine sulfate is a derivative of 4-aminoquinoline, which is an inhibitor of autophagy and has antimalarial, anticancer and anti-rheumatoid activities. The mechanism of action of chloroquine is not completely understood. But, some studies have demonstrated that hydroxychloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. In addition, while hydroxychloroquine can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. (The product is for research purpose only.)
References
- The Role of Autophagy in Cancer: Therapeutic Implications
- Targeting autophagy in cancer (a review)
- Antimalarial Agents: Chloroquine, Hydroxychloroquine, and Quinacrine (a review)
- Hydroxychloroquine: from malaria to autoimmunity
- Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications
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