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Published TCIMAIL newest issue No.197
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CAS RN: 1405-10-3 | Product Number: F0649
Fradiomycin Sulfate
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Purity: >97.0%(N)
Synonyms:
- Neomycin Sulfate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€46.00
|
2 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | F0649 |
| Purity / Analysis Method | >97.0%(N) |
| Molecular Formula / Molecular Weight | C__2__3H__4__6N__6O__1__3·3H__2SO__4 = 908.87 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| CAS RN | 1405-10-3 |
| Related CAS RN | 1404-04-2 |
| Reaxys Registry Number | 9468364 |
| PubChem Substance ID | 87560000 |
| Merck Index (14) | 6454 |
| MDL Number | MFCD00077833 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(with Total Nitrogen) | min. 97.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | +55.0 to +61.0 deg(C=10, H2O)(calcd.on dried substance) |
| Drying loss | max. 8.0 % |
Properties (reference)
| Specific Rotation | 56° (C=10,H2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 215-773-1 |
| RTECS# | QP4375000 |
Transport Information:
| HS Number | 2941900000 |
Application
RNA aptamer research
References
- Recognition of a cognate RNA aptamer by neomycin B: quantitative evaluation of hydrogen bonding and electrostatic interactions
- A novel RNA motif for neomycin recognition
Application
Fradiomycin or Neomycin: A Broad Spectrum Aminoglycoside Antibiotic
Fradiomycin or neomycin, an aminoglycoside antibiotic, is first isolated in 1949 from the gram-positive bacillus Streptomyces fradiae. It consists of a mixture of two isomers, fradiomycin B and fradiomycin C. Fradiomycin has broad activity against Gram-negative bacteria except Pseudomonas aeruginosa and Gram-positive bacteria. It binds with bacterium ribosome 30s, and then it inhibits bacterial growth by inhibiting protein synthesis.
References
- Neomycin
- Aminoglycoside antibiotics: structure, functions and effects on in vitro plant culture and genetic transformation protocols
- Aminoglycoside-nucleic acid interactions: the case for neomycin
- Antimicrobial agents. Part II. The aminoglycosides. Streptomycin, kanamycin, gentamicin, tobramycin, amikacin, neomycin
- N. S. Brewer, Mayo Clin. Proc. 1977, 52, 675.
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